Mammillaria dixanthocentron is not particularly difficult on own roots. No special cultural requirements. Growth rate: It is an easily flowering species and a relatively rapid grower in comparison to other spherical species, the plant will increase the number of heads by dichotomous division. Large clumps can be produced in a few years given the best conditions. Soils: It likes very porous standard neutral or slightly alkaline cactus mix soil. Repotting: Use pot with good drainage. Watering: It should be watered generously during the growing season, but do not overwater (Rot prone), keep dry in winter. Water it less than average if in bigger pots, small pots preferred. Fertilization: Feed with a high potassium fertilizer in summer. Hardiness: Reputedly sensitive to frost, but less so if kept on the dry side prior to, and during, cold weather. However warmth throughout the year will increase the grower's success (8-12°C during rest season). Exposition: Outside bright, hot conditions or afternoon shade, inside it needs bright light, and some direct sun. Strong light encourages flowering and heavy wool and spine production.